2021 IEEE International Conference on Acoustics, Speech and Signal Processing

6-11 June 2021 • Toronto, Ontario, Canada

Extracting Knowledge from Information

2021 IEEE International Conference on Acoustics, Speech and Signal Processing

6-11 June 2021 • Toronto, Ontario, Canada

Extracting Knowledge from Information
Login Paper Search My Schedule Paper Index Help

My ICASSP 2021 Schedule

Note: Your custom schedule will not be saved unless you create a new account or login to an existing account.
  1. Create a login based on your email (takes less than one minute)
  2. Perform 'Paper Search'
  3. Select papers that you desire to save in your personalized schedule
  4. Click on 'My Schedule' to see the current list of selected papers
  5. Click on 'Printable Version' to create a separate window suitable for printing (the header and menu will appear, but will not actually print)

Paper Detail

Paper IDBIO-5.2
Paper Title UNCERTAINTY-BASED BIOLOGICAL AGE ESTIMATION OF BRAIN MRI SCANS
Authors Karim Armanious, Sherif Abdulatif, Wenbin Shi, University of Stuttgart, Germany; Tobias Hepp, Max Planck Institute for Intelligent Systems, Germany; Sergios Gatidis, University of Tübingen, Germany; Bin Yang, University of Stuttgart, Germany
SessionBIO-5: Neuroimaging and Neural Signal Processing
LocationGather.Town
Session Time:Tuesday, 08 June, 14:00 - 14:45
Presentation Time:Tuesday, 08 June, 14:00 - 14:45
Presentation Poster
Topic Biomedical Imaging and Signal Processing: [BIO-MIA] Medical image analysis
IEEE Xplore Open Preview  Click here to view in IEEE Xplore
Abstract Age is an essential factor in modern diagnostic procedures. However, assessment of the true biological age (BA) remains a daunting task due to the lack of reference ground-truth labels. Current BA estimation approaches are either restricted to skeletal images or rely on non-imaging modalities which yield a whole-body BA assessment. However, various organ systems may exhibit different aging characteristics due to lifestyle and genetic factors. In this initial study, we propose a new framework for organ-specific BA estimation utilizing 3D magnetic resonance image (MRI) scans. As a first step, this framework predicts the chronological age (CA) together with the corresponding patient-dependent aleatoric uncertainty. An iterative training algorithm is then utilized to segregate atypical aging patients from the given population based on the predicted uncertainty scores. In this manner, we hypothesize that training a new model on the remaining population should approximate the true BA behavior. We apply the proposed methodology on a brain MRI dataset containing healthy individuals as well as Alzheimer’s patients. We demonstrate the correlation between the predicted BAs and the expected cognitive deterioration in Alzheimer’s patients.